The tired, often uncomfortable effects that one encounters after the high from smoking strong weed.
Bob: Yo what was that shit called?
Billy: That was some straight GDP nigga, Granddaddy Purp
Bob: Damn that's some shit mang i was so blazed
Billy: Yea bro, but you gotta be careful if u smoke too much of that shit u could get some bad karma
Bob: Yea i did, but it was well worth it