Term of derision generally used by uneducated individuals. Usually is intended to imply that the subject of the insult is a "sissy" or an "egghead."
This of course is merely indicative of envy on the part of the individual using the insult.
Schmuck: "Man, look at that punk-ass college boy. What a pansy, he thinks he knows so much."
College Boy: "Man, look at that schmuck. It must suck to work so hard for so little money. He should have gone to college