Like confusion, except without the badness. Confusion usually has bad/negative connotations associated with it. Confuzzion is more like a merf/blah feeling, while still maintaining a certain level of imbecilic ignorance.
Joe: Hello, Raquel, what is wrong with you?
Raquel: Well, Joe, I am not suffering from confusion. I am experiencing a bit of Confuzzion. I cannot decide what to do.
Joe: Well that is easy. The answer is 42.