Gonnohepaherpamydia

The worst STD you can possibly imagine. Characterized by seeping, puss-filled gangrenous warts in, on, and around the genitals. The strongest strains originate in the cities of Rochester, Amsterdam, and Gloversville NY (where it is often acquired from dealers of drugs such as cocaine and heroin)

You: Man, I wanna fuck that Allie chick down at the convenience store...

Your Friend: Naw man, she's got the gonnohepaherpamydia

You: Aww, shit, son. That's just fuckin' nasty.