Cinco de mayo nuke Share definition Flag The next day after cinco de mayo when you regret in the bathroom all the spicy food you ate the day before . Pedro had a cinco de mayo nuke after all the hot and spicy food he ateRIP Pedro Cinco de mayo nuke by MR.Mister April 25, 2013 0 0 Get merch Get the Cinco de mayo nuke mug. Buy Now — $32.95 See more merch