Top definition
The guilt that comes with leaving your city for a more affluent area after college, despite the best attempts of your professors and others to prevent it.
Paul: "I had this crazy dream last night. I was on trial for planning to move to Chicago, but the jury was made up of my professors. When the judge asked for the verdict, one of them stood up and said, "We have no verdict. We're just extremely dissappointed in him."

Bob: "Sounds like you have a serious case of brain drain guilt bro."
by Simon Dylan May 26, 2011
Get the mug
Get a brain drain guilt mug for your sister-in-law Riley.