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A syndrome in which someone is horribly deformed, which in turn makes the person look like "Sloth" off the popular 1985 movie the Goonies. This is to be used to insult someone that is horrible looking.
"Dude don't laugh that kid, Ashton, has Goonies Syndrome"---Ricky
"WOW! she does look like Sloth"---Clyde
by nspectrmustache October 09, 2010
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