When an unfortunate event such as being knock down and the person who "knock you down" said sorry, you would say Dude, It's Fine.

This also can be use to piss someone off like Cool Story Bro.
Dude 1: I'm sorry for running over your cat.
Dude 2: Dude, It's Fine she have 8 more lives.

Dude 1: Why the hell would you like her that I thought you were going to to put in a good word for me.
Dude 2: Dude, It's Fine.
Dude 1: No, It's not fucking fine!
by Nate the Great April 5, 2012
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Common expression of disagreement from a shitfacedindividual on their current level of shitfacedness.
Guy 1: You sure you can drive? You're pretty drunk, you can't even walk!

Guy 2: Nah dude I'm fine. *pukes in Guy 1's lap*

Guy 1: Fuckin drunktard...
by st1kypalmz December 12, 2009
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