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Allegedly, here in the backwoods of the Appalachian area redneck drunks used to mix some sort of painting chemical (lacquer thinner, paint thinner, acetone or some other chemical) with Kool-aid and once mixed the concoction smoked... thus "drinking smoke"

The term is usually used to describe someone who is wigging out (tripping, high seeing things) or acting exceedingly stupid, in a manner that it would appear the person had been drinkin' smoke.
(sees someone acting stupid...) Hey, you been drinkin' smoke?

(your friend tells you he spent 100 bucks on some flip flops) point and exclaim, "drankin' smoke"
by Gotthemstacksholla September 24, 2013
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