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Defoe Syndrome is a severe physical condition where the body starts to mutate. The legs start to get cellulite all over them. Then the upper lip amazingly gets shorter and shorter until it suddenly dissapears making closing your mouth nearly impossible.

Defoe Syndrome originates in the DeFoe Family starting with Steve and will unfortunately linger on if any female is crazy enough to have Steves Diagnosed DeFoe Syndrome babies.
"Steve what happened to your upper lip? And why are your legs so fat? Oh nevermind, he just has the DeFoe Syndrome."
by Tim Hanks June 29, 2006
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