Definition #1: A disease contracted in "the hood" whilst having intercourse with a "ratchet" "hoodrat".

Definition #2: A generic term to identify a grotesque disease.
Example Definition #1:
Person #1: Hey, did you hear about Jigaboo Jones having sex with Susie Rottencrotch?

Person #2: Yeah, I heard that nigga got cucamongous.

Example Definition #2:
Person #1: Hey bro, I got something on my lip. Can you see what it is?

Person #2: That shit look like cucamongous, bruh! Get yo ass away from me!
by The Spectre July 10, 2014
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