To have an extramarital affair in another country, especially South America.
South Carolina Governor Mark Sanford was hiking the Appalachian Trail last week and didn't tell anyone where he was, but he's really really sorry about it.
by Ken Starr June 24, 2009
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Made famous by South Carolina Governor Mark Sanford, it's a euphemism for when you're doing something nefarious.
Randy: Hey, were you out messin' around with that tranny again?

Daryl: Nah, dude. I was hiking the Appalachian Trail.
by Butler CW June 25, 2009
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