titbrain Share definition Flag An insult used rarely. Can be heard when someone cannot think of another insult. Could literally mean a person who has a tit for a brain Frank! what are you doing!?! you are a total....erm.... titbrain. titbrain by Hull Advice October 24, 2006 0 0 Get merch Get the titbrain mug. Buy Now — $32.95 See more merch