lobotofuck Share definition Flag Fucking the hole in someone's head after they've had a lobotomy. Often used similarly to skullfuck. Dude, I was lobotofucking the hell out of her.Dude... Ew. lobotofuck by Tron55000 November 2, 2017 0 0 Get merch Get the lobotofuck mug. Buy Now — $32.95 See more merch