Opiholic Share definition Flag Someone who is addicted to Opiates, such as Vicodin, Percocet, or OC's, and the person is an Alcoholic, too. "Damn, did you see that nasty frog looking broad? Dude, she looks like a Opiholic, in denial". Opiholic by T-Niggles May 9, 2009 0 0 Get merch Get the Opiholic mug. Buy Now — $32.95 See more merch