Refers to any situation in the Left 4 Dead video game series when a group of 2 or more special infected pick on 1 survivor in a single ambush.
Bill: Son, are you ok!?
Louis: Nah dude, I just got special raped.
When one uses the bathroom during a game of Left 4 Dead, it is considered a Bile Break.
Player1: "Ready to start the roller coaster"
Player 2: Wait! I gotta take a bile break!