Top Definition
A depressed feeling one gets from constantly having to move around or not being able to stay in one place. Comes from having to always zip up ones jacket because they always have to leave. Depression caused by successive movement and not being able to settle in one place. Frustration caused by constant mobility and inability to maintain a residence.
Amy's fifth move in one year caused her to experience zipper blues.
by Monday May 18, 2006
pent up sexual frustrations meaning lack of sex & intimacy
The guy in the 40year old virgin movie had zipper blues.
by smashingpumpkins, March 19, 2010
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