Cocaine. The actualy spelling is llello. The use of yayo came about after some wannabe punk kids thought it was spelled that way. Fuckers.
"Sling llello and yo ass is smack."
by Ashby January 02, 2004

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A nickname for tobacco that you snort.
Last week we got buzzed off that yayo.
by Be96 February 19, 2011

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Yayo is the spanish word "llello". To make it easier for the english people to pronounce it properly they said "yayo". It sounds the same thing is spanish so STOP TRIPPIN!!!!!!
Man yesterday i sold an ounce of that yayo.
by Brandon October 03, 2004

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the act of making someone snort a line of your semen while you have sex doggy style
Joe yayo'd that girl last night, she wont be able to breath right for a week.
by Deathorglory February 04, 2010

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cocaine ... this is the proper spelling yet people believe it is correctly spelled "llello". (usually people who have used the drug several times and belive they know how it works)
I railed a diesel sized line of yayo.
by jgrizz September 01, 2003

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-Cocaine also known as coke.Often a term used bya thug or gangster.
-It is actually a spanish word spelled llello, however, it has been,like many other words, americanized.
Example:
Thug- Yo dawg , can you hook a g up with some yayo?
Thug's homie- Yeah dude, how much you want?
Thug- About a gram yo.
by bizel October 05, 2005

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I users term to describe the horrible drug Cocaine.

Shortened versions(IE. Yay, Yo) are also the same thing.

Tip: Stay away from this drug
Hey bro, I just got 20 bucks, lets go get some Yayo
by User wanting to quit April 13, 2006

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