It typically means "what's up" or "how are you doing" or "how's your day?
Friend: Hi Steph, What's poppin, what's Gucci?

Stephanie: Hey!!! Nothing much wbu?
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The first thing you should ever say to anyone ever in the history of the entire world I guess (also use 🅱️ At the end of every sentence after the statement what’s poppin 🅱️ Has been said)
What’s poppin 🅱️
Nothing much 🅱️
That’s rad...🅱️
Yeah 🅱️
🅱️
🅱️🅱️
🅱️🅱️🅱️
K🅱️
Bye 🅱️
by Frack man February 18, 2018
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Used to replace any word with a beginning letter of b. Bro, Babe, bae, etc.
by FlyingTiger455 August 30, 2017
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This is a greeting meant to say what's up, what's crackin', or another such colloquial greeting. The reason it is popular is because Poppin' Fresh is the Pillsbury Doughboy's former name (the name was changed to update little Freshy's character and bring him into modern times). The phrase is not questioning what Poppin' Fresh is, rather it is using poppin' in it's slang meaning, and it is using fresh as a noun, not an adjective. Fresh refers to the person being addressed by the question.
Bob: Yo
Joe: Yo, what's poppin' fresh?
Bob: Not much kid, what's crackalackin'
by Marley June 16, 2006
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Commonly used as a greeting/text. Can be extremely cringey at times, however if it used ironically, it's ok. 'B' is short for, 'Babe', 'Bae', 'BB' and so on.
Boy: Hey, what's poppin b? X

Girl: Um, your a bit fucking weird.
by What's good my dood March 1, 2017
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What's poppin and lockin? is a saying for when you want to know what your friend is up to?
A : Hey, "what's poppin and lockin?" tonight?

B: Nothing much, "what's popping and locking?"...with you?
by Theodore Ovaltine September 9, 2009
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