To be "up with the put-down" is to be in the know-how; to have the latest information/gossip or to fully understand a situation.
Character 1: "What? I doooon't get iiiittt...?!?!"
Character 2: "OMFG, grrrrlllll, get up with the fxing put-down. here's how it's done..."

Scene Kids on the Street: *RAMBLE RAMBLE RAMBLE. GOSSIP GOSSIP GOSSIP. SEX SEX SEX. PARAPHANELIA, PEDOPHILIA, DRUG ABUSE*

Street Cop Strolling By: "Wow, great job staying up with the put-down, kids. Keep it up!"
by Nick Hoover June 3, 2008
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A disease caught by picking up too many cards in UNO when playing by the rule "Pick up until you can put down" when needing a card.
Michael:"I Change colour to Blue"
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.
by NinjaSlayer_936 January 2, 2021
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