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To consume so much Cocaine that it eventually rots the flesh between the nostrills leaving the user with just one large hole in the nose. Normally followed by reconstructive surgery (for the rich and famous).
Have you seen the state of his nose?

He's done that much Coke he's got a unistrill.
by Quidj April 09, 2008

Words related to unistrill

cocaine coke nose nostrill user