Top Definition
A fight between two or more people on twitter. Most commonly with one side suffering a severe mental issue causing said twuffle in the first place.
Consisting of, but not limited to; fight, battle, tussle, scuffle, war.
Consisting of, but not limited to; fight, battle, tussle, scuffle, war.
I'm in a twuffle with Audi's marketing team over Twitter best practices. It's terribly one-sided.
by TwuffleMaster
April 26, 2011
1 more definition
2
a person who is everything nothing and something all at the same time.
you are a twuffle.
by ellamendez
October 29, 2014
