two o'clock whore Share definition Flag A woman or girl who you would never dream of calling or contacting before two o'clock in the morning. Alright, bar's closed so I'm going to the two o'clock whore's house to see if she is still awake. two o'clock whore by progressives October 24, 2009 0 0 Get merch Get the two o'clock whore mug. Buy Now — $32.95 See more merch