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2.
Anyone who is unduly enamoured of the Twilight books/movies. Such individuals are typically characterized by their obsession with Edward Cullen, the main protaganist of the series, and lack any rationality or intelligence when it comes to the subject.
Edward Cullen Look-Alike: Hello.
Twisexual Girl: Oh my God, you look just like him! (immediately bends over)
Edward Cullen Look-Alike: *fap* *fap* *fap*

Edward Cullen Look-Alike: Hello.
Twisexual Guy: Oh my God, you look just like him! (immediately bends over)
Edward Cullen: *fap* *fap* *fap*
by TheSovietCollossus July 02, 2010
 
1.
Someone who wants to have an orgy with the cast of Twilight
I'm a Twisexual
by greenday22 April 27, 2011
 
3.
someone who loves a twilight character
girl: "i love edard cullen!!"

guy: "what a twisexual..."
by Lehmon February 22, 2009
 
4.
A male who's into the twighlight series for one reason only... to pick up chicks
Mary: OMG your into the twighlight series?

Dave: Sure am... wana hook up?

Mary: OK

Dave: who'd have known being a TWISEXUAL would pay off
by Twisex January 29, 2010
 
5.
loving Team Edward and Team Jacob aka wanting to bang edward and jacob
J: Last night while with my boyfriend, I was thinking of both Edward and Jacob...Does this mean I'm twisexual?

Ayesha: I mean...it's bad for you...i already twifucked both of them
by Ayesha721 July 04, 2010