A guy who acts like a girl and is an overall vagina about things. a.k.a. a pussy bitch. This word is by far the most insulting of the "pussy" arsenal.
Dude #1: "Dude Bryson is a total bitch about everything. He can't do anything right and he utterly sucks at life."
Dude #2: "Yeah man, he is a total Titty Bitch."