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Acronym for "the internet is serious business," seen in many popular internet jokes. Used when people get too vehement or serious about their forum posts/discussions by making passive/aggressive ad hominem attacks.
"Take a chill pill dude, anyone with half a brain can see that Emilio Bonifacio is the worst 3B in the league judging by half a dozen sabermetrics that if you'd taken 30 seconds to research you would have seen yourself. I don't need to come down to your level to make this case to you."

"Dude, TIISB. Take it easy."
TIISB by Skoodog April 28, 2009
Related Words

Tiisetso Buff 

This refers to the ability of Tiisetso's to get away with literally anything and everything in existance.
Trust. You wont get in trouble, you have the Tiisetso Buff.
A very cool/sick* object or noun.
Omg, That is sooo tiish!’ or ‘What a tiish meal dat was!’
Tiish by Dat.tiish.one December 30, 2018
Tiiso is an outgoing, fun and adventurous girl🔥❤. She is so smart and so kind, she is a sweetheart everyone loves tiiso. She is kind of an introvert, kinda shy person but if you get to know her better you are going to love her so freaking much. In setswana tiiso means strength 💪. And indeed she gives us all strength with her love and care. Arghhhhh, honestly you wouldn't resist tiiso.
She is my tiiso.she is my strength 💪
tiiso by Mystery girl here November 24, 2021
Ke lerete.If you fuck around he might just chow your hun. He's also an intellectual meaning he's too smart for motherfuckas.
Did you hear the story of how Tiiso chowed both Omphile and Tshidi's huns at the same time?
Tiiso by Dont ask, just read November 25, 2021

Ti is mean and funny 

Ti can be really mean sometimes but it weighs off bc she is very funny
Man ti be making me mad but she funny ti is mean and funny
Ti is mean and funny by Big cel December 12, 2021