In sports, the opposite of "win and in"; describes a team's situation entering a game in which if the don't come out victorious, they are eliminated from postseason (the diffuse element is derived from the fact that the players on the team will go their separate ways at the conclusion of the season).
Man, if the Giants don't win this week, they can't make the playoffs.

Yeah dude, it's 'lose and diffuse' this week.
by T. Coughlin December 22, 2010
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losing feelings falling out of love, or you care about that person but you just love them as a friend now example: its best if you let the person go cause the more y'all stay the more y'all will get hurt even worse maybe its just best as friends or if you know there is something give it a few days make sure that person is happy give them attention so they will know the're loved
im losing feelings for this girl i dont feel anything inside me left for her
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To lose one's mind/marbles. Refers to when an individual forgets obvious things or makes easy mistakes, similarly to the symptoms of going senile.
'You're losing on yourself because you put your shoes in the fridge!'

Amy is losing on herself because she confused a person with a cat.
by Giant Mushrooms June 1, 2011
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Get really angry and lose your self-control. Derogatory, as implies that it wasn't a reasonable reaction in the circumstances.
After Dad saw my picture on the front of the porno DVD, he completely lost the plot.
by Observer52 August 23, 2005
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A saying used by hoes and douches. Commonly used when they are breaking up with someone. After a couple days they will come back asking for forgiveness
Sorry Ben I’m just losing interest

Izzy I’m losing interest”
by Paint can May 28, 2019
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A term that simply points out someones misfortune or lack of attaining or owning something they desire.
Big Jon: I want LSD and a Speed Cut Defencer

Beej: You have speedcut AND no LSD????? You loose!!!
by Beej December 6, 2004
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When an idiot boyfriend treats a girl like she doesn't matter. When he has her trust and loses it by cheating on another girl.
oh did you see that boy? he was losing trust.
by hjifghnictg November 11, 2008
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