AIDS. A deadly STD caught from tainted "fish".
Stay away from that skag unless you want to end up with the deadliest catch.
by wolfbait51 March 30, 2011
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1. Deadliest Catch: The title of a Discovery Channel reality series about guys who catch crabs. Narrated by Mike Rowe.

2. Deadliest Catch with Tila Tequila: The possible title of a new MTV reality series about guys who catch crabs. (lol, thank you Jimmy Fallon!)
I love Deadliest Catch! Only on Discovery though, just thinking of the MTV version makes me itch...
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Pretty much the best show on the Discovery Channel. Its about the most dangerous job in America. It takes place in the Bering Sea in Unalaka Alaska. Someday I will be a greenhorn!
by Corrie Modica June 9, 2007
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a horrible STD that can ultimately kill you.
I know that AIDS can kill you, but I honestly think that syphilis is the deadliest catch.
by JONODE July 9, 2011
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A woman who has no business wearing fishnet stockings but wears them anyway.
"Dude, did you see that fat chick in the fishnets?"
"Yeah, she's the deadliest catch"
by josev October 26, 2012
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