Major Spelling Mistake 

Basically all of r/ihadastroke.
A major spelling mistake is different from a minor spelling mistake because a minor spelling mistake is commonly used to easily win an argument and doesn't matter; a major spelling mistake is fact, and when made, the recipient(s) of the letter blender have a choice on how to use this.

This is an example of a major spelling mistake between friends:
Person 1: Did you get your photos printed?
Person 2: Bogksmos bingvtesd?
Person 1: I uh...
Person 2: Sorry, I messed that up a lot. Anyways, yes, I did.
*Nice conversation*

This is an example of a major spelling mistake between enemies of any kind:
Person 1: Did you get your photos printed?
Person 2: Bogksmos bingvtesd?
Person 1: Major spelling mistake, I win + bankrupt + ratio + you're bad.
Person 2: D:
*Everything bad*

Major Spelling Mistake by Rubixed Cube March 23, 2022

Minor Spelling Mistake 

A goofy thing you do that makes you lose an argrument

Joe: "You're mother is fat and ugly'
Quandavious: "Minor Spelling Mistake L bozo"

Minor Spelling Mistake by criry August 16, 2022

ratio + fatherless + minor spelling mistake 

Will win every agruement

person 1: bro u gay llo
person 2 ratio + fatherless + minor spelling mistake I win

ratio + fatherless + minor spelling mistake by Getty imaegs February 9, 2022

Spilling mistake 

When a spell-checker corrects a mistake into a valid word which is different than the one originally intended.

"Make sure your paper has no spling mistakes before submitting" corrected to "Make sure your paper has no spilling mistakes before submitting".

Spilling mistake by Urban2K May 11, 2014