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2.
a fictional disease that originates amongst the homeless population (specifically the ones that live in boxes).

Every day, millions of homeless men and women contract the disease "Smallbox." in order to cure these helpless people we must force them to get into the box. the only cure is the box itself.

Symptoms include:

Claustrophobia

poor hygiene
"herpegonasiphilaids"
rash on your underarms

we must find a cure
wow Erin's Smallbox is really bad, maybe she should have gotten into the box instead of rip it up and put it on my bed.
by Squishy Squishy ear August 27, 2009
 
1.
a tight little unit, aka vagini
"would you like small box?" said the pizza hut waitress
"yes please" said jason
by RGDUB September 21, 2006