Someone who has done to many drugs, and now has impaired sences, judgement, motor skills etc. Another way of saying "perma fried".
That kid is so skull fried... Oh well. He'll realize what hes done to himself in a few years...
by immediate_kontrol June 01, 2007
to be seriously messed up on drugs
"wow man im fuckin skullfried after smokin that blunt"
by chezz(P.I.) March 29, 2007