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Prescription narcotic cough syrups. Most contain Hydrocodone or Codeine. These syrups have other ingredients in them for treating cold and cough symptoms, such as Antihistamines or Decongestants.

Some Common Formulas:
Tussionex- 10mg Hydrocodone (Extended-Release) and Chlorpheniramine 8mg per 5ml (1 tsp.)
Codiclear/Hycotuss- Hydrocodone and Guaifenesin
Lortab Elixir- Hydrocodone and Acetaminophen
Prometh VC with Codeine: Codeine and Promethazine

Often people will add Alcohol, Flavorings (ex. Kool-Aid), or crushed-up pills (such as Vicodin) to potentiate the effects of the syrup or make it taste better.

A somewhat common misperception is that Sizurp refers to over-the-counter cough syrups containing DXM (dextromethorphan) which some abuse ("Robotrippin") for its dissassociative effects.
From Three Six Mafia, Sippin on Some Sizzurp:

"I got the wet promethazine, thick orange & yellow tuss
Hydroco-done...Sippin on Some Sizurp..."
Sizurp by WSB15 April 11, 2006
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n.
1. An illegal effervescent cocktail beverage consumed by hoods.
a. Recipe: One part strawberry soda (8oz), one part cough syrup (Dextromethorphan HBr), one teaspoon crushed codeine. Shake mixture well; drink cold.

b. Recipe (optional): One part cough syrup (Dextromethorphan HBr), one part ginger ale soda.
Sizurp by Matt Hoyt February 10, 2004
sizurp-prescription cough syrup, usually tussionex(10mg of hydrocodone/teaspoon)mixed with nyquil and cool-aid.
how much for that sizurp?
$40 for just one ounce!!
Sizurp by j. saint.r October 17, 2003
Cough syrup + sprite = sizurp and you gotcha self a deal
Sizurp by jjjamarion25 October 8, 2018
a mix of codeine and cough syrup served martini style with alcohol
36 MAFIA, crush codeine and mix with strong cough syrup, then add to shaker with somerhing like gin and juice
Sizurp by wej johnson March 15, 2003
sizurp is the reference to prescription cough syrup containing hydrocodone and/or promethizine
tussionex, pancof
Sizurp by j. saint.r October 17, 2003
Sizerp is a mix of a cough syrup that contains codeine and some type of vodka. This combination will cause you to hallucinate.
We were sippin on that sizerp last night.
Sizerp by Dhoffman October 27, 2006