when someone acts jelous
yo..she actin mad sisty because you go out with her ex
by Keeshia February 15, 2005
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its pretty much combining sister and bestie together
Sistie! I love you.

That's my sistie, even tho were sisters, she still my bestie.
by Domexigringa December 10, 2016
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A spoonerism for "ugly sisters." Originally referring to the characters in Cinderella, this fun little phrase can be brought out whenever you have to refer to a friend or loved one's less than charming female siblings.
1. (usage for a lover) "Oh Crap, I promised Bob I'd spend Christmas with him, but I didn't realize his Sisty Uglers would be there too."

2. (Usage for a friend) "Jane, you know I think you're awesome, but your effin Sisty Uglers always give me attitude."
by Kay Tor June 6, 2009
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A burst of uncontrollable and built up physical and vocal anger and hatred.
Julia went Sisti mode on my ex who got with that dumb skank
by Fatcock30897 March 16, 2022
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