Top Definition
a person that is very close to you and you love like a sister. you tell them everything and are best friends. you are almost always with each other. sista frans are BEYOND just friends
Shea: is that girl Katie your friend?
Carly: She's not only my friend, she's my sista fran

Katie: hey sista fran, what's up?
Carly: nothing much, wanna hang out. go shopping or something?
by runnergirl365 February 05, 2011
When you get excited you can refer to the person you're talking to as Sistafran.
"I am a communist."
by Mike I May 06, 2005

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