Top Definition
When you feel gross for a reason, of which you can do nothing about.

Stomach can actually feel like it cramps and you want to be sick, however, being sick will just make you feel even more 'sick in the guts' and more than likely have a sore head and foul taste in your mouth afterwards.

It may help to pick blades of grass, pull loose threads or fling rubber bands at random objects.

Furthermore, smile whenever you swallow spit - feels good doesn't it?
Jimmy said something he shouldn't have and he couldn't take the words back, hence causing Jimmy to feel 'sick in the guts'.

Sister slang of 'crook in the guts'.
by wordchunda August 07, 2011

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