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1.
the appropriate and necessary response after someone says something really stupid or annoying or if you just want someone to shut up because you can't stand their useless, nonstop jibber jabber any longer. coined for the intolerable sam meyers
sam: "blah blah blah i'm so cool blah blah blah i live in DC and go to bars and hit on 15 yr olds blah blah blah i am in love with the uc president blah blah blah i go to galas blah blah i heart pirates blah blah blah i want to live in cotton plant blah blah blah i drunk dialed my mom blah blah blah..."

dani: "SHUT UP MEYERS!!!!!!"
by randall November 06, 2004
 
2.
it means "i'm an idiot"
Dani: Shut up, Meyers!
Sam: I know.
by uh anonymous November 11, 2004