Common reply to when does something horribly fucked up, cringe, or just down bad.
Example 1:

(Degenerate)Person 1: Oh my god bro we just kicked this kitten on the street it was so funny

Person 2: Shoot This Motherfucker

Example 2:

(Degenerate)Person 1 : Haii guys!!! UWU!
Person 2: The fuck is wrong with you? Shoot this motherfucker.
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