sherfuck holmes Share definition Flag a girl who is a slut, whore, or easy to have sexual relations with. Thus, she is a "sure-fuck". -You had sex with Amanda? -Yea -That's nothing to brag about, she is a "sherfuck holmes". sherfuck holmes by Alex216 March 24, 2008 0 0 Get merch Get the sherfuck holmes mug. Buy Now — $32.95 See more merch