Abbreviation of the Bavarian greeting "Servus". Originally used by bumbklaat as "sers" or "sers ^^", meanwhile adopted by other people and oftenly used to express...nothing.
(19:08:10) <bumbklaatt> sers ^^
(19:08:16) <FlashTT> sers ^^
by Unhit November 20, 2003
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Another way of saying yes, si, or serp. When typing or when writing, you can add as many "r's" as you want. (serrrr)this just makes it more emphasized.
"What do you want to do today....tu modge?"

"Serrr."
by alisnotaman April 20, 2008
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Unisex version of sir/madam. Gained popularity on crypto twitter
by dk_belly_wasp September 16, 2021
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An intentional, genderless misspelling of the word "sir" often correlated with Pepe the frog and used in internet sub-culture Discord, Reddit, and Telegram chats, particularly in the cryptocurrency community.
Hello ser, when will the project be launching?

Gm sers, hope you all had a lovely weekend.
by hykenfreak January 11, 2023
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is it pos for someone to be def ser about something that is def not pos to be ser about
by kingss49 January 31, 2003
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Smooth Endoplasmatic Reticulum. Regions of Endoplasmatic Reticulum that lack bound ribosomes. Sometimes called transitional ER because they contain ER exit sites from which transport vesicles carrying newly synthesized proteins and lipids bud off for transport to the Golgi apparatus.
the newly synthesized proteins are transported from the SER to the Golgi apparatus
by heatcliff April 2, 2005
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