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1.
The terror, dread and pain one feels when experiencing fecal urgency without having access to the facilities to relieve themselves.
'I was driving back from the steakhouse and was running with the devil all the way home. I think I broke my zipper trying to get my pants down getting to the toilet!'
by five5six April 30, 2010

Words related to running with the devil

embarrassing fear pain shit smash
 
2.
To lead a risk-filled, thrill-seeking, hedonistic lifestyle. Also the title of a song by the musical group Van Halen.
"You see this woman on a TV show/She’s dripping in diamonds from head to toe/They make you believe it’s the status quo/You’re running with the devil; it’s touch and go"

- "Touch And Go", Emerson, Lake & Palmer
by Darth_Stimpy September 27, 2004