Top Definition
/noun/ occurance in which a plain-looking child star becomes SEXY AS ALL HELL after going through puberty; named after Keisha Knight Pulliam's character on "The Cosby Show;" also known as the punky brewster effect
Keisha Knight Pulliam, Alyssa Milano, & Soleil Moon Frye all have rudy huxtable syndrome.
by The Deuce December 16, 2005
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