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Refers to threads on a screw, nut, bolt, etc. To tighten, you turn to the right (clockwise). To loosen, you turn toward the left (counter clockwise). A few exceptions exist, notably old propane cylinders and some pipe fittings.
"How do I get this screw out?"
"Righty tighty lefty loosy!"
by Okie Dokie December 08, 2005