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1. The inability to control one's penis, and, therefore fucking everything in sight. Generally it is men who are afflicted with this disease.
2. An excuse whoring men give for being unfaithful.
"Baby, it's not my fault you caught me with the Maytag repair man in a 69! It's my Restless third-leg syndrome acting up".
by poojones13 August 23, 2007
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