a.) to take an active role

b.) to participate in a game of cards

c.) to not fold in card games like poker where folding occurs -- often uesd with a possesive pronoun, e.g. play my hand, play your hand
Does God play a hand in our lives, or does he just watch?

Hey, we're about to start a game of Texas Hold 'Em. Want to play a hand?

Jimmy looks confident. I don't know if I should play my hand or fold.
by Louis Tsunami February 9, 2008
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To play the lone hand, she or he is masturbating.
Since Jim didn't call, Heather decidedto play the lone hand.
by Cranberry Bob December 4, 2019
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When a couple is constantly putting their hands on each other, sexually and otherwise, in enclosed public spaces.
Tom: I gave my brother and his girl a ride to the movies yesterday, but they kept playing hands in my backseat.
Dick: Dude, they ever heard of too much PDA?
by JasonD May 4, 2015
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