Top Definition
to get all upset over something trivial, as if one's underwear has rolled up into an uncomfortable ball between one's butt cheeks
Cheri: "Did you see what he did to my iPod? I can't believe he put that song on there."
Bobbi: "Oh don't get your panties in a wad over it, you can always take it off."
by nerak December 28, 2006

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