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1.
Getting off with someone to get over someone else.
Girl 1: "I can't stop thinking about Jack"
Girl 2: "What you need is a good palette cleanser!"
by secretblah July 15, 2012
 
2.
Something eaten after a particularly intense meal/snack to get the flavor out of your mouth. A good palette cleanser tastes relatively subtle or bland.
Yeowch, these Altoids set my mouth on fire! I need me a good palette cleanser. Do we have any Fritos?
by Gulstab August 25, 2009