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1.
Cheerios with poppy seeds sprinkled on them; Short for Opium O's.
"I like to eat my opi-o's with a spork!"
by M_word May 05, 2006
 
2.
Smoke rings blown after inhaling opium.
"I can make opi-os!"
-Ralph Wiggum
by Thundermonkey1992 November 02, 2010