(1) to be said when you get pwned in a video game.
(2) to be said in relation to someone saying something that sparked memory of something you have forgotten.
(3) to be said when someone has had something bad happen.
(1) OH PISS i just got DESTROYED, where is my face?
(2) *josh* hey english sucked yesterday *fred* yeah no joke.
*you* OH PISS my homework.
(3) *josh* yeah dude i was parking my car and some jackass cut me off and smashed my ride. *response* OH PISS dude that SUCKS