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1.
When something that could possibly goes wrong - in fact - does go wrong .

Therefore making someone say (to themselves), "of course", in a sarcastic tone.
"Badass! I just got GTA IV for PC and I have better than recommended system requirements!"

*Installs Game*

"...And its laggy as hell..." OF COURSE

©"Of Course Theory"
by Tickbaby January 16, 2010