An adapted quote from the movie Aliens, to 'nuke it from orbit' means 'to come in a woman's face'

One step up from kill it with fire, usually followed by the phrase "it's the only way to be sure."

A paraphrasal of Ripley's line in the 1986 film 'Aliens': "I say we take off and nuke the entire site from orbit. It's the only way to be sure."

Generally used in response to a clusterfuck, or anything largely weird or gross that needs killing or otherwise dealing with.