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2.
An adapted quote from the movie Aliens, to 'nuke it from orbit' means 'to come in a woman's face'
"That bitch's face annoys me"

"I'll be chucking one up her later, if it makes you feel any better, I'll nuke it from orbit"
by cancermerchant August 13, 2008
 
1.
One step up from kill it with fire, usually followed by the phrase "it's the only way to be sure."

A paraphrasal of Ripley's line in the 1986 film 'Aliens': "I say we take off and nuke the entire site from orbit. It's the only way to be sure."

Generally used in response to a clusterfuck, or anything largely weird or gross that needs killing or otherwise dealing with.
Mike: Guys, termites have invaded my house, what should I do?
Dave: Nuke it from orbit!
by mush01 July 30, 2008